Enterin has identified a series of small compounds originating in the dogfish shark, which can prevent alpha synuclein (αS) – the culprit in Parkinson’s Disease (PD) – from accumulating within the nerves of the gastrointestinal (GI) tract. Our lead compound is called kenterin (ENT-01). Alpha synuclein will stick tightly to certain types of membranes, especially those that line the inside of nerve cells. Membrane bound molecules of αS have a tendency to clump together, much more so than when they are freely floating within a cell. It is these ‘clumps’ or aggregates that damage the nerve cell; they are also called ‘Lewy Bodies’ after the scientist who first recognized them.
Kenterin has the remarkable property of entering the nerve cell, attaching itself to the nerve’s membrane, and dislodging αS. If αS can’t bind to a membrane, it can’t form aggregates. It’s that simple. There are no other known drugs on market or in development that act via this mechanism of action. We have shown success in two preclinical animal models of Parkinson’s Disease as well as a Phase 1/2a study completed in 2018. The results of that study will be posted in 2019.
As of December 2018, we are taking ENT-01 (kenterin) into Phase 2b for the treatment of constipation associated with PD. Neurolgic symptoms will also be evaluated. ENT-01 will be an oral capsule or tablet, since its site of action will be topically in the gut. Additional clinical trials will follow thereafter.
We are assessing ENT-01’s ability to deliver the following outcome in those with Parkinson’s Disease:
- Correction of constipation
We will also be exploring ENT-01’s ability to deliver the following outcomes:
- Improvement in sleep architecture
- Improvement in temperature regulation
- Improvement in mood, with reduced depression and anxiety
- Improvement in cognition
- Improvement in nocturnal visions/delusions/hallucinations